Synthesis, characterization and biological activity of some adamantane containing benzimidazole

Author: Aleksandre Vanishvili
Keywords: Adamantane, Benzimidazole, Heterocycles, Antiviral drugs
Annotation:

The study concerns the synthesis of 2- (1-adamantylmethyl) -1H-benzimidazole 5 '(6') -R 'substituted products. 2- (1-adamantylmethyl) -1H-benzimidazole 5 '(6') -benzophenone and 2- (1-adamantylmethyl) -1H-benzimidazole 5 '(6') -carbohydrazide were synthesised, which reacted with aromatic aldehydes to give the corresponding Schiff base. . During the research period, the synthesis of N-3- (5-nitro-1H-benzimidazol-2-yl) adamantan-1-yl) acetamide was studied and the corresponding products were obtained by its conversion. The structure of the obtained substances was determined using IR and 1NMR spectroscopic methods. Test the biological activity of the obtained substances through the online program (PASS - Prediction of Activity Spectra for Substances).

Lecture files:

Synthesis, characterization and biological activity of some adamantane containing benzimidazole [en]
ზოგიერთი ადამანტანშემცველი ბენზიმიდაზოლის სინთეზი, დახასიათება და ბიოლოგიური აქტიურობა [ka]