Study of the process of drug release from microemulsions prepared on the basis of nonionic surfactants

Author: rusudan chaladze
Keywords: drug release from microemulsion, difusion exponent, kinetic constant, nonionic surfactant
Annotation:

The release profile of antihistamine 10-[2-(dimethylamino) propyl] phenothiazine hydrochloride from microemulsions was studied in the present work. Microemulsions were prepared on the basis of nonionic surfactants: polyoxyethylene (20) cetyl ether, polyoxyethylene (4) lauryl ether, polyoxyethylene (23) lauryl ether and polyoxyethylene (20) sorbitan monooleate. A phosphate buffer (pH = 7.4) was used as a release medium i.e. as a receptor solution, and the donor phase was a drug dissolved in a microemulsion. Experiments were carried out by dialysis using cellulose membranes.