The adaptive mechanism of liver in response to hyperglycemic functional stress in alloxan induced diabetes

Author: Merabi Sepashvili
Keywords: Diabetes mellitus, Alloxan, Endoreplication, Liver, Rat, Adaptation mechanism
Annotation:

Diabetes mellitus represents a serious medical and social-economical problem because of its spread level and effects on disablement and life expectancy. The mentioned pathology is characterized by a lack of insulin synthesis or non-effective uptake of produced insulin. Recent studies and research have shown a decrease of high ploidy (2c×2) hepatocytes within one month of injection of alloxan or streptozotocin drug in Diabetes mellitus experimental models. The described phenomenon can be explained by a decrease of insulin concentration, which controls cytokinesis, and accordingly the amount of high ploidy cells during cytoskeleton reorganization. Nevertheless, the changes in correlation between diploid and high ploidy cells is not investigated at the initial phase of disease (within the first 48 hours) when extreme changes in glucose concentration are indicated. The aim of the presented work was to study the adaptive mechanism of the liver in response to hyperglycemic functional stress. It was found that in 48 hours after alloxan injection there is no significant change in hepatocyte mitotic activity. Nevertheless, the amount of 4c cells in liver is significantly increased (p<0.05) Formation of high ploidy hepatocytes (presumably G2-0 population) without changes in proliferation activity in response to increased functional stress on liver during initial phase (within the first 48 hours) of alloxan induced diabetes (white adult rat experimental model) is an adaptive peculiarity of the organ.

Lecture files:

ალოქსანური დიაბეტის პირობებში ჰიპერგლიკემიით გამოწვეული ფუნქციური დატვირთვის საპასუხოდ ღვიძლის ადაპტაციის მექანიზმი [ka]