Study of the effectiveness of PCL / antibiotic nanoparticles on microb candida by physico-biological methods "

Author: salome chinchaladze
Co-authors: Elene Lomadze
Keywords: PCL nanoparticles, Candida, Ketoconazole
Annotation:

The paper discusses one of the most pressing issues related to the action of antibiotics on microbes. Many scientific centers are working on this topic, as there are already many pathogenic microbes that are resistant to antibiotics. In our paper we studied the microbe Candida albicans, which is a pathogenic fungal microbe (non-bacterial), is widespread and at the same time it easily infects the human digestive system. At the same time it should be noted that since it is a microbe of non-bacterial origin, its destruction is possible only with the action of certain types of strong antibiotics. We know that taking antibiotics on the one hand gives us both positive and negative results because it acts on harmful and beneficial bacteria or microbes and destroys them. In our case of the antibiotic, ketoconazole we have placed in the PCL nano particle, which has the function and provides the delivery of the drug without damaging the specific target cells and releasing the drug in that area. To determine the effectiveness of the PCL nanoparticle drug complex , we conducted experiments using the turbidimeter and disc method, which showed that the nanoparticle drug complex was much more effective than the freely delivered drug.