Modulatory effect of creatine on the process of the interaction of the NMDA-receptor and the Na+/K+ ATPase under the long-term psycho-emotional stress

Author: Natia Guliashvili
Co-authors: Nana Koshoridze, Mariam Shengelia
Keywords: stress, social isolation, circadian rhythm, hippocampus, NMDA-receptor, enzyme Na+/K+ ATPase, creatine
Annotation:

Social isolation and disturbances in natural circadian rhythm are important stress factors effecting a range of metabolic pathways in the cell, in particular, there is a decrease of energy processes and the activity of the antioxidant system. Various enzyme systems are involved in these processes. Notable among them is the enzyme Na+/K+ ATPase, which is particularly highly active in the brain and is actively involved in the functioning of the nervous system. However, the role of the enzyme Na+/K+ ATPase and the nature of the activity change under stress is quite obscure. It is known that the activity of the enzyme Na+/K+ ATPase is related to the work of the glutamate NMDA-receptor. Presumably, the decrease in the activity of the enzyme Na+/K+ ATPase is due to the activation of the NMDA-receptor under stress and the increase concentration of calcium ions in the cell. It is known that the increase of calcium ions is cytotoxic and contributes to the development of a number of pathological processes. It is especially important to find a compound that can modulate NMDA-receptor activity and therefore protect the body from pathological changes. In this case, an interesting substances is creatine, which has a modulatory role in NMDA-receptor activity. This research aimed to determine how does the change of the activity of the NMDA-receptor influence the change of the activity of the enzyme Na+/K+ ATPase and the modulatory role of creatine in NMDA-receptor activity under conditions of long-term psycho-emotional stress, which is correlated with the changes of the activity of the enzyme Na+/K+ ATPase.