The Identification and comparative characterization of the endogenous growth inhibitory factor from variously transformed human nerve cells

The quantitative and qualitative analysis of the components of the thermostable protein complex isolated from human brain cells transformed to different degrees was carried out. It has been shown that the endogenous thermostable protein complexes inhibiting cell proliferation isolated from benign (adenohypophysis) and malignant (glioblastoma) tumor brain cells differ by the quantitative amount of active component (calmodulin). It has also been established that the thermostable protein complex derived from the adenohypophysis adenoma does not inhibit the proliferation of the cells in adolescent rats, which is explained by the minor content of active components in it. At the same time, it has been shown that the stimulating effect on the proliferation of liver cells in adolescent rats by the thermostable protein complex derived from the glioblastoma is due to the high amount of androgen receptors in these cells and the major content of the active component (calmodulin) in the complex that functionally binds to receptors.