Synthesis of 6 (1H-indol-2-yl) quinazolin-2,4-diamine

New heterocyclic quinazoline ring containing system 6- (1H-indol-2-yl) quinazoline-2,4-diamine has been synthesized. The process obtaining striking product has held in two steps, based on 2-(paraaminophenyl) indole. In the first step, 2-(paraaminophenyl) indole interacted with sodium dicyanamide in diphenylformamide. The intermediate was obtained monoguanidine (N-cyano-N- (1H-2 phenylenedol-4-yl) guanidine. The monoguanidine was cyclized with polyphosphoric acid at 80-85 ° C to give the target product 6 (1H-indol-2-yl) quinazolin-2,4-diamine. In order to increase the yield of the products, the optimal conditions for the interaction of the obtained intermediate monoguanidine and polyphosphoric acid were selected. The biological activity of the newly obtained heterocycle is remarkable for screening new pharmaceutical preparations.

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